Nv Generate Mr Brain Finetune
NVIDIAOfficialCreated by NVIDIA MedTech Team
- Skill
- Tool integration
- Data and AI
- Apache-2.0
- Medium risk
- Has scripts
AutoGineer summary
Written by AutoGineer from the skill’s own files, not by the author
This skill provides a structured wrapper to finetune the NV-Generate-CTMR MR-Brain v1 diffusion UNet. It automates the staging of configuration files, latent embedding generation, and training execution by delegating to upstream scripts. The skill supports various MRI modalities including T1, T2, FLAIR, SWI, and MRA. It is designed for research and experimentation, explicitly excluding clinical, regulatory, or production data approval use cases.
What it does
- Stages configuration JSONs for training and inference workflows.
- Generates latent embeddings from NIfTI training volumes.
- Executes diffusion UNet training using user-supplied data.
- Supports optional inference runs for immediate sanity checking.
- Provides a preflight mode to validate datalists without GPU training.
- Manages environment and dependency requirements for upstream script execution.
When to use it
- When you need to adapt the MR-Brain v1 model to specific MRI training data.
- When performing initial validation of a new datalist using the preflight feature.
- When you want to monitor training progress via TensorBoard.
- When you need to generate custom brain MRI volumes for qualitative research.
Advantages
- Automates complex configuration staging for upstream training scripts.
- Provides a consistent interface for both preflight validation and full GPU training.
- Allows for flexible hyperparameter tuning via standard JSON configuration files.
- Supports multiple MRI modalities within a unified workflow.
Usage examples
- “Validate my MRI T1 datalist for finetuning.”
- The agent runs the skill in preflight mode, checking the datalist and data directory structure without initiating GPU training.
- “Finetune the MR-Brain model on my T1 dataset for 2 epochs.”
- The agent executes the training script with the specified datalist, data root, and epoch count, producing a finetuned checkpoint.
Install
Download the skill as a ZIP:
https://autogineer.com/agent-skills/nvidia/nv-generate-mr-brain-finetune/downloadUnzip it into the cross-client skills folder of your project:
mkdir -p .agents/skills && unzip nv-generate-mr-brain-finetune.zip -d .agents/skills
Documentation by NVIDIA MedTech Team
NV-Generate-MR-Brain-Finetune
Purpose
Used for finetuning the NV-Generate-CTMR
rflow-mr-brainv1 diffusion UNet from user-supplied T1, T2, FLAIR, SWI, or MRA NIfTI training volumes.Not for clinical interpretation, regulatory use, or approving synthetic data for production training.
The wrapper stages the config glue locally and delegates execution to existing upstream scripts:
scripts.diff_model_create_training_data,scripts.diff_model_train, and optionallyscripts.diff_model_infer. It does not execute the notebook.Manifest I/O: inputs are
datalistanddata_base_dir; outputs arefinetuned_checkpoint, optionalinference_outputs, andresult_json.The underlying training contract is the upstream config/env JSON (the same one driven from cell
[10]oftrain_diff_unet_tutorial.ipynb). The wrapper stages those JSON files for you and exposes the most-tuned fields as CLI flags; the sections below document the fields, their defaults, and how to monitor/tune a run.
Instructions
Read
skill_manifest.yamlbefore changing arguments, side effects, or validation gates.Run
scripts/run_mr_brain_finetune.pyfrom the Medical AI Skills repo root.If a host agent exposes
run_script, userun_script("scripts/run_mr_brain_finetune.py", args=[...]); otherwise run the Bash/Python command below.For a command-shape review, do not install packages, clone repositories, download weights, or start GPU training. Emit only the wrapper command with the supplied datalist, an explicit
--data-base-dir, an explicit--output-dir, and the requested modality.When the user explicitly asks for a training-launch command, do not silently replace it with
--preflight; include--preflightonly for a preflight request.Use
--preflightfirst when checking a new datalist; remove--preflightonly when the user explicitly wants to launch GPU finetuning.For a staged preflight input bundle directory, use
BUNDLE/preflight_datalist.jsonas the datalist andBUNDLE/preflight_datasetas--data-base-dirwhen those files are present.
Examples
Validate and stage a preflight finetune check from an input bundle (the recommended first step — no GPU, no training). This is the single canonical command; replace INPUT_BUNDLE and OUT_DIR with your paths:
export NV_GENERATE_ROOT="${NV_GENERATE_ROOT:-$HOME/.cache/nvidia-skills/upstreams/NV-Generate-CTMR-da438fe}" && \
python skills/nv-generate-mr-brain-finetune/scripts/run_mr_brain_finetune.py \
INPUT_BUNDLE/preflight_datalist.json \
--data-base-dir INPUT_BUNDLE/preflight_dataset \
--output-dir OUT_DIR \
--modality mri_t1 \
--preflightFor real GPU finetuning and other variations, see Usage below.
Command-shape review for a requested training launch (no setup or execution):
python skills/nv-generate-mr-brain-finetune/scripts/run_mr_brain_finetune.py \
PATH_TO_DATALIST.json \
--data-base-dir PATH_TO_DATA_ROOT \
--output-dir runs/nv_generate_mr_brain_finetune \
--epochs 2 \
--modality mri_t1Available Scripts
| Script | Purpose | Arguments |
|---|---|---|
scripts/run_mr_brain_finetune.py | Primary entrypoint declared by skill_manifest.yaml. | DATALIST.json --data-base-dir DATA_DIR --output-dir OUT_DIR [--epochs N] [--modality mri_t1] [--num-gpus N] [--no-amp] [--model-config FILE] [--download-model-data] [--run-inference] [--preflight] |
Prerequisites
An explicit
NV_GENERATE_ROOTmay point to the caller's local checkout and must containscripts/diff_model_create_training_data.py,scripts/diff_model_train.py, andscripts/diff_model_infer.py. The result records its current commit.If
NV_GENERATE_ROOTis unset, the wrapper searches.workbench_data/upstreams/NV-Generate-CTMR.CUDA_VISIBLE_DEVICESis optional and can be used to select the GPU for real training.Runtime requirements: NVIDIA CUDA GPU for real training, Python packages from the upstream
requirements.txt, and downloaded MR-brain weights.Side effects: writes staged configs, embeddings, checkpoints, optional inference images, and logs under the caller-provided
--output-dir; may write model caches under the upstream checkout and~/.cache/huggingface/; may contacthttps://huggingface.cofor model assets andhttps://github.comfor the upstream checkout.The datalist is a MONAI-style JSON object with
training[].imagepaths relative to--data-base-dir.training[].modalityis optional and defaults tomri_t1.
When no local checkout is supplied, create the recommended pinned default checkout once:
if [ -z "${NV_GENERATE_ROOT:-}" ]; then
export NV_GENERATE_COMMIT=da438fec6484cdb6f421f8c7051d954ebefff730
export NV_GENERATE_ROOT="$HOME/.cache/nvidia-skills/upstreams/NV-Generate-CTMR-da438fe"
if [ ! -d "$NV_GENERATE_ROOT/.git" ]; then
git clone https://github.com/NVIDIA-Medtech/NV-Generate-CTMR.git "$NV_GENERATE_ROOT"
git -C "$NV_GENERATE_ROOT" checkout --detach "$NV_GENERATE_COMMIT"
fi
fiThe wrapper executes upstream code only when NV_GENERATE_ROOT is at the exact
manifest commit and its tracked files are clean. Supply custom training and
inference settings through the documented config flags rather than editing the
checkout. Child processes receive only an allowlist of runtime, CUDA, locale,
and certificate variables; API keys, tokens, passwords, and unrelated parent
environment values are not forwarded. The public v1 assets do not require a
credential; pre-download them if your network setup requires separate tooling.
Before a GPU run, download the exact autoencoder and MR-Brain v1 checkpoint
revisions declared by the manifest. Passing --download-model-data performs
these same two pinned downloads:
python -m huggingface_hub.commands.huggingface_cli download \
nvidia/NV-Generate-CT models/autoencoder_v1.pt \
--revision 75ac080fb1083c403793563477724c038e7d430c \
--local-dir "$NV_GENERATE_ROOT"
python -m huggingface_hub.commands.huggingface_cli download \
nvidia/NV-Generate-MR-Brain models/diff_unet_3d_rflow-mr-brain_v1.pt \
--revision ef9759bf221265b2704569cdeeac20bbf03b62ee \
--local-dir "$NV_GENERATE_ROOT"1. Config and environment JSON (adapt to your data)
This is a thin wrapper around the upstream train_diff_unet_tutorial.ipynb flow. Each run performs four steps, delegating the heavy lifting to the model author's scripts:
Stage configs — copy the three config JSONs and rewrite only the run-specific paths and
n_epochs(notebook cell 15).python -m scripts.diff_model_create_training_data→ latent*_emb.nii.gzembeddings (cell 17).Write embedding sidecars — a
<emb>.nii.gz.jsonper embedding withspacing/modality(and body-region indices when the model uses them). This is the one piece of glue that lives in the notebook (cell 19), not in upstreamscripts/, anddiff_model_trainrequires it; the skill owns it.python -m scripts.diff_model_train(cell 21), optionallypython -m scripts.diff_model_infer.
Tune by editing the config JSON, not by adding flags. All training/inference hyperparameters (lr, batch_size, cache_rate, inference dim/spacing/num_inference_steps/cfg_guidance_scale, …) live in config_maisi_diff_model_rflow-mr-brain.json. Edit the upstream copy, or pass your own with --model-config FILE (and --env-config / --model-def for the other two). The wrapper only ever rewrites the fields below.
Environment JSON (environment_maisi_diff_model_rflow-mr-brain.json) — fields the wrapper rewrites per run:
| Field | Set from | Notes |
|---|---|---|
data_base_dir | --data-base-dir | Root for relative training[].image paths. |
json_data_list | your datalist | Staged copy with per-entry modality filled in. |
embedding_base_dir, model_dir, output_dir | --output-dir | Latent embeddings, checkpoints, inference images. |
modality_mapping_path | upstream | Maps modality name → integer code. |
model_filename | --model-filename | Output checkpoint name (default diff_unet_3d_rflow-mr-brain_v1.pt). |
existing_ckpt_filepath | upstream weights / --existing-ckpt-filepath | Starting checkpoint; cleared by --train-from-scratch. |
trained_autoencoder_path | upstream weights / --trained-autoencoder-path | VAE used to encode/decode latents. |
Model config (config_maisi_diff_model_rflow-mr-brain.json) — the only fields the wrapper touches:
| Field | Set from | Default | Notes |
|---|---|---|---|
diffusion_unet_train.n_epochs | --epochs | 2 (upstream config ships 1000) | Convenience override (cell 15 does the same); wrapper default is small for verification. |
diffusion_unet_inference.modality | --modality | from modality_mapping.json | Kept consistent with the training modality for optional --run-inference. |
Everything else in that file (lr, batch_size, cache_rate, the rest of diffusion_unet_inference) is left exactly as written — edit the JSON to change it.
The pinned v1 inference block defaults to dim=[256,256,128],
spacing=[0.94,0.94,1.36], and cfg_guidance_scale=2. The wrapper preserves
those fields. Older v0 examples may show 256^3, 1 mm spacing, and guidance
scale 10; use the staged v1 JSON as the execution source of truth.
Runtime flags (not config fields): --num-gpus N (>1 launches torch.distributed.run), --no-amp (disable mixed precision, passed through to diff_model_train).
--modality selects the integer code from configs/modality_mapping.json.
Supported brain values include mri (8), mri_t1 (9, default), mri_t2
(10), mri_flair (11), mri_mra (16), mri_swi (20), and the
skull-stripped values mri_t1_skull_stripped (29),
mri_t2_skull_stripped (30), mri_flair_skull_stripped (31),
mri_swi_skull_stripped (32), and mri_mra_skull_stripped (33). Per-case
training[].modality overrides --modality. The modality also feeds the
step-3 embedding sidecars. Upstream reports sparse MRA training coverage, so
MRA output quality is not guaranteed.
For an end-to-end reference including example data download and checkpoint loading, see the upstream tutorial train_diff_unet_tutorial.ipynb.
2. Usage (one-line training)
Preflight only:
export NV_GENERATE_ROOT="${NV_GENERATE_ROOT:-$HOME/.cache/nvidia-skills/upstreams/NV-Generate-CTMR-da438fe}" && \
python skills/nv-generate-mr-brain-finetune/scripts/run_mr_brain_finetune.py \
PATH_TO_DATALIST.json \
--data-base-dir PATH_TO_DATA_ROOT \
--output-dir runs/nv_generate_mr_brain_finetune_preflight \
--preflightPreflight bundle input:
export NV_GENERATE_ROOT="${NV_GENERATE_ROOT:-$HOME/.cache/nvidia-skills/upstreams/NV-Generate-CTMR-da438fe}" && \
python skills/nv-generate-mr-brain-finetune/scripts/run_mr_brain_finetune.py \
PATH_TO_INPUT_BUNDLE/preflight_datalist.json \
--data-base-dir PATH_TO_INPUT_BUNDLE/preflight_dataset \
--output-dir runs/nv_generate_mr_brain_finetune_preflight \
--preflightGPU finetuning:
export NV_GENERATE_ROOT="${NV_GENERATE_ROOT:-$HOME/.cache/nvidia-skills/upstreams/NV-Generate-CTMR-da438fe}" && \
python -m pip install -r "$NV_GENERATE_ROOT/requirements.txt" && \
python skills/nv-generate-mr-brain-finetune/scripts/run_mr_brain_finetune.py \
PATH_TO_DATALIST.json \
--data-base-dir PATH_TO_DATA_ROOT \
--output-dir runs/nv_generate_mr_brain_finetune \
--epochs 2 \
--modality mri_t1 \
--run-inferenceReplace PATH_TO_DATALIST.json and PATH_TO_DATA_ROOT with the user's actual paths. Do not use the fixture datalist for real training; it is a preflight-only placeholder.
3. Monitor training (TensorBoard)
scripts.diff_model_train writes TensorBoard event files under the staged model_dir (OUT_DIR/artifacts/models). Launch TensorBoard against the output directory and watch the loss curve:
python -m pip install tensorboard && \
tensorboard --logdir runs/nv_generate_mr_brain_finetune/artifactsThe run summary is written to OUT_DIR/artifacts/workflow_summary.json (checkpoint path, embedding sidecars, inference outputs); the JSON the wrapper prints to stdout mirrors the same paths plus exit_code and a stderr_tail for quick triage.
4. Hyperparameter tuning and common pitfalls
Loss not decreasing / unstable — lower
diffusion_unet_train.lr(default1e-5) in the model-config JSON, or keep AMP on (default);--no-ampis slower but more numerically stable on older GPUs.Out-of-memory — keep
diffusion_unet_train.batch_sizeat1andcache_rateat0in the config JSON, and confirm the autoencoder/UNet fit your GPU before scaling. Multi-GPU (--num-gpus N) shards the batch viatorch.distributed.run.Few cases / quick check — keep
--epochssmall (the wrapper default2is for verification, not convergence; the upstream config ships1000).Wrong modality conditioning — set
--modalityor per-casetraining[].modalityto a value present inconfigs/modality_mapping.json; a mismatch produces a clear error rather than silently mislabeling latents.Slow startup on first run —
diff_model_create_training_dataprecomputes latent embeddings once; reuse the same--output-dirto avoid recomputing them.
5. Evaluate the finetuned model
Use the staged checkpoint (OUT_DIR/artifacts/models/<model_filename>) as the diffusion UNet for generation, then inspect the synthesized volumes:
Pass
--run-inferencehere for a quick built-in sanity render, orPoint the
nv-generate-mr-braininference skill at the finetuned checkpoint to generate fresh brain MRI volumes for qualitative review.
This skill gates file accounting and command provenance only — anatomical realism and downstream utility must be judged by a domain expert on the generated images.
Limitations
Requires a current upstream
NV-Generate-CTMRcheckout with the existing diffusion training scripts. The skill itself stages the required config and datalist glue locally and does not depend on the notebook or PR #33.Full training can be expensive and is not deterministic across hardware, CUDA, and package versions.
The wrapper gates file accounting and command provenance, not anatomical realism or downstream model utility.
Not for clinical deployment, clinical interpretation, autonomous diagnosis, regulatory submission, or production training-data approval.
Troubleshooting
| Error | Cause | Fix |
|---|---|---|
diffusion training scripts were not found | NV_GENERATE_ROOT does not point at a current NV-Generate-CTMR checkout. | Clone or update https://github.com/NVIDIA-Medtech/NV-Generate-CTMR and set NV_GENERATE_ROOT. |
missing datalist image | training[].image paths are not relative to --data-base-dir or files are absent. | Fix the datalist or pass the correct data root. |
| CUDA or MONAI import failure | Runtime environment lacks upstream dependencies. | Install "$NV_GENERATE_ROOT/requirements.txt" in the selected environment. |
Files
- ATTRIBUTION.mdAdded by AutoGineer958 B
- BENCHMARK.md7.6 KiB
- LICENSELicence file added by AutoGineer11.2 KiB
- SKILL.md15.3 KiB
- evals/evals.json2.0 KiB
- fixtures/README.md228 B
- fixtures/preflight_datalist.json130 B
- fixtures/preflight_dataset/imagesTr/placeholder_mri_t1.txt133 B
- scripts/run_mr_brain_finetune.pyScript30.2 KiB
- skill-card.md4.8 KiB
- skill.oms.sig6.2 KiB
- skill_manifest.yaml7.4 KiB
- tests/test_run_mr_brain_finetune.pyScript10.1 KiB
- validators/output_schema.json4.2 KiB
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Requirements and compatibility
Works with: Claude Code, Claude apps, OpenAI Codex, GitHub Copilot, Cursor, Gemini CLI, Kiro, OpenCode, Goose, Amp, Roo Code, JetBrains Junie, Factory Droid, Devin (ex-Windsurf), Mistral Vibe, OpenHands, Letta
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Needs: Declares allowed tools, Needs an API key, Needs a command-line tool, Needs Python
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Attribution and licence
- Created by
- NVIDIA MedTech Team
- Publisher
- NVIDIA (Official)
- Source
- NVIDIA/skills · skills/nv-generate-mr-brain-finetune · commit fce3cca
- Licence
- Apache License 2.0 (redistribution allowed)
- LICENSE (added by AutoGineer from LICENSE-APACHE)
- ATTRIBUTION.md (written by AutoGineer)
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